ARP 101 is a selective MMP-2 inhibitor with IC50 value of 0.81nM. MMP-2 is an enzyme and involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction and tissue remodeling, as well as in disease processes, such as arthritis and metastasis . ARP 101 shows inhibition of fibrosarcoma HT1080 cell growth in vitro. ARP 101 has shown ~250 fold selectivity of MMP-2 over MMP-1 and ~100 fold of MMP-9 over MMP-1 . ARP 101 proved to be 15.3 and 24.7 times more potent than compound a and CGS 27023A on MMP-2, maintaining a different selectivity and potency of MMP-2/MMP-1 compared with inhibitor Prinomastat and CGS 27023A .

Product information

CAS Number: 849773-63-3

Molecular Weight: 406.50

Formula: C20H26N2O5S

Chemical Name: (2R)-N-hydroxy-3-methyl-2-[N-(propan-2-yloxy)[1,1'-biphenyl]-4-sulfonamido]butanamide

Smiles: CC(C)[C@H](C(=O)NO)N(OC(C)C)S(=O)(=O)C1C=CC(=CC=1)C1C=CC=CC=1

InChiKey: DGZZVIWCMGVHGV-LJQANCHMSA-N

InChi: InChI=1S/C20H26N2O5S/c1-14(2)19(20(23)21-24)22(27-15(3)4)28(25,26)18-12-10-17(11-13-18)16-8-6-5-7-9-16/h5-15,19,24H,1-4H3,(H,21,23)/t19-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.